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Levodopa leads to significant improvements in motor symptoms in the majority of people.In some people in the early stages of Parkinson’s disease, it leads to virtually normal motor movement.A Parkinson’s treatment revolution was sparked by the late 1950s discovery that dopamine was located primarily in a part of the brain called the striatum.
Hyoscyamine and other anti-cholinergic drugs would remain the primary means of treatment for the next 100 years.
This was followed by the application of substances to induce blistering of the skin and the insertion of small pieces of cork into these blisters to lead to pus discharge. The basis of Parkinson’s is loss of cells that normally produce the neurotransmitter dopamine in an area of the brain called the substantia nigra.
The involvement of the substantia nigra has been known since the late 19th and early 20th century.
This releases the drug over a longer period of time (four to six hours), leading to steadier levels of levodopa in the blood.
But because of the slow release, the beneficial effects of Sinemet CR may take longer to come about.